Jinxing Xia

Abstract Therapeutic vaccination for chronic hepatitis B (CHB) remains challenging, as persistent immune tolerance to hepatitis B surface antigen (HBsAg) impedes anti-HBsAg seroconversion. Here we show that screening antigen combinations incorporating HBsAg identifies preS1-HBsAg as the optimal pairing.

Microenvironment-activated nanoparticles for oxygen self-supplemented photodynamic cancer therapy† Hang Liu,‡a Wei Jiang,‡b Qin Wang,b Jinxing Xia,c Wenhao Yu,a Yucai Wang *b and Yanmei Wang *a Author affiliations * Corresponding authors a CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, P. R.

Microenvironment-Activatable Nanoparticles for Oxygen Self-Supplemented Photodynamic Cancer Therapy Tumor hypoxia, as a hallmark of most solid tumors, poses a serious impediment to O2-dependent anticancer therapies, such as photodynamic therapy (PDT). Although utilizing nanocarriers to load and transport O2 to tumor tissues has been proved effective, the therapeutic outcomes have been impeded by the low O2 capacity and limited tumor penetration of the nanocarriers.