Skip To Main Content
Jinyin Zha on Muck Rack

Jinyin Zha

As seen in: Nature, Royal Society of Chemistry
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Jinyin

Contact Jinyin, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Designing drugs and chemical probes with the dualsteric approach

|
By Jinyin Zha, Jixiao He, Chengwei Wu, Mingyang Zhang
| Royal Society of Chemistry Verified
Designing drugs and chemical probes with the dualsteric approach Traditionally, drugs are monovalent, targeting only one site on the protein surface. This includes orthosteric and allosteric drugs, which bind the protein at orthosteric and allosteric sites, respectively. Orthosteric drugs are good in potency, whereas allosteric drugs have better selectivity and are solutions to classically undruggable targets.
Open in Who Shared Issue with article?

Encoding Molecular Docking for Quantum Computers

|
By Jinyin Zha, Jiaqi Su, Yin Ma, Chongyu Cao
| dx.doi.org
Molecular docking is important in drug discovery but is burdensome for classical computers. Here, we introduce Grid Point Matching (GPM) and Feature Atom Matching (FAM) to accelerate pose sampling in molecular docking by encoding the problem into quadratic unconstrained binary optimization (QUBO) models so that it could be solved by quantum computers like the coherent Ising machine (CIM). As a result, GPM shows a sampling power close to that of Glide SP, a method performing an extensive search.
Open in Who Shared Issue with article?

Spatiotemporal and global profiling of DNA–protein interactions enables discovery of low-affinity transcription factors - Nature Chemistry

|
By Hao Hu, Jinyin Zha, Yechun Xu, Dongxin Zhao, Jian Zhang, Minjia Tan
| Nature Verified
Author notes These authors contributed equally: An-Di Guo, Ke-Nian Yan, Hao Hu. Authors and Affiliations State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China An-Di Guo, Ke-Nian Yan, Hao Hu, Linhui Zhai, Haixia Su, Yijia Chi, Yechun Xu, Dongxin Zhao, Xiaojie Lu, Minjia Tan & Xiao-Hua Chen University of Chinese Academy of Sciences, Beijing, China An-Di Guo, Ke-Nian Yan, Yijia Chi, Dongxin Zhao, Minjia Tan & Xiao-Hua Chen...
Open in Who Shared Issue with article?
See all 4 articles