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Jinying Ding on Muck Rack

Jinying Ding

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Articles

Self-limiting population suppression gene drive design in the West Nile vector mosquito, Culex quinquefasciatus

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By Xuechun Feng, Yiran Liu, Valentino M. Gantz, Xue-Xin Chen, Jackson Champer, Feng Liu, Jinying Ding
| Nature Verified
Abstract Culex quinquefasciatus is a major vector of West Nile virus and other pathogens, yet genetic population suppression tools for this species remain limited. Here, we develop a self-limiting, CRISPR-based suppression gene drive system targeting doublesex, close to the male-determining locus, promoting male transmission. A recoded dsxM sequence converts females into sterile intersexes, preventing population-level spread.
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