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Jiongzhou Wu on Muck Rack

Jiongzhou Wu

As seen in: ACS Publications
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Articles

Chemical Information Modeling for Component-Level Review Prioritization of Adverse-Reaction Signals in Multi-Component Medicines Click to copy article link Article link copied!

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By Bowen Shi, Shuyan Zhang, Jiongzhou Wu
| ACS Publications
Abstract Click to copy section linkSection link copied! Postmarketing safety signals for multicomponent medicines are usually assigned to a whole product, leaving unresolved which component chemistry should be reviewed first. We formulate this problem as chemical information modeling over a heterogeneous safety graph connecting Kampo formulas, crude-drug components, ingredients, protein targets, protein–protein interactions, and adverse-reaction terms.
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