Jiqian Xu

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ARDS is a syndrome including heterogeneous phenotypes with variable clinical and outcome characteristics, and PP is not effective in every case owing to the heterogeneity of ARDS, which highlights the necessity of further studies of the predictors of PP effectiveness. Until now, no criteria have predicted which patient will benefit from PP.

Originally published15 Feb 2022https://doi.org/10.1161/CIRCULATIONAHA.121.055841Circulation. 2022;0 Abstract Background: Calcium (Ca2+) is a key regulator of energy metabolism. Impaired Ca2+ homeostasis damages mitochondria, causing cardiomyocyte death, pathological hypertrophy, and heart failure. This study investigates the regulation and the role of the mitochondrial Ca2+ uniporter (MCU) in chronic stress-induced pathological cardiac remodeling.