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Jiuhong Nan

As seen in: Nature
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Articles

Tau aggregates cause reactivation of transposable DNA elements, leading to Z-RNA–ZBP1-mediated neuronal death

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By Wei Liu, Bo-Xin Zhang, Shuang-Hui Guo, Lang Li, Wenjing Sun, Xushen Xiong, Jianfeng Wu, Linghui Zeng, Pilong Li, Zhi-Yu Cai, Shuo Zhang, Sheng Nie, Baizhou Li, Dan Wu, Xuchen Qi, Dong Fang, Wei Chen, Yingying Zhang, Qiang Chen, Zhang-Hua Yang, Jiahuai Han, Wei Mo, Song-Ang Wu, Jiuhong Nan, Huan-Feng Ye
| Nature Verified
Abstract Once tau aggregates are formed, their neurotoxicity significantly contributes to neuronal death and cognitive decline in tauopathies, with Alzheimer’s disease being the most well-known example. Despite its central pathogenic role, however, effective therapeutic strategies targeting the neurotoxicity of tau remain poor. Here we demonstrate the pathogenic role of neuronal cell death in tau-related neurodegeneration (PS19 mouse model).
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