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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
Lipid-organized tetramerization of PLPP1 defines the molecular basis of spatial lipid phosphate signaling
Abstract Bioactive lipid phosphates, such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate, are potent membrane-embedded signals that regulate fundamental processes in development, immunity, and cancer. The termination of these signals is mediated by phospholipid phosphatases (PLPPs), yet the molecular principles governing their function at the membrane interface have remained poorly understood.
Primate-specific regulation of the human glycosphingolipid gatekeeper UGCG
Abstract Glycosphingolipids are essential membrane components that organize lipid microdomains and orchestrate cellular signalling, differentiation and neuronal function1,2,3,4. In humans, these functions arise from a repertoire of several hundred glycosphingolipid species generated through stepwise glycan elaboration5,6.
Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs - Cell Discovery
Abstract Gout, a common and painful disease, stems from hyperuricemia, where elevated blood urate levels lead to urate crystal formation in joints and kidneys. The human urate transporter 1 (hURAT1) plays a critical role in urate homeostasis by facilitating urate reabsorption in the renal proximal tubule, making it a key target for gout therapy.
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