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Jiuyin Xu on Muck Rack

Jiuyin Xu

As seen in: Nature, BioRxiv
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Articles

Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs - Cell Discovery

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By Jiuyin Xu, Xinheng He, Youwei Xu, Mingwei Wang, Dehua Yang
| Nature Verified
Abstract Gout, a common and painful disease, stems from hyperuricemia, where elevated blood urate levels lead to urate crystal formation in joints and kidneys. The human urate transporter 1 (hURAT1) plays a critical role in urate homeostasis by facilitating urate reabsorption in the renal proximal tubule, making it a key target for gout therapy.
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Structural Insights into Selective and Dual Antagonism of EP2 and EP4 Prostaglandin Receptors

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By Yanli Wu, Heng Zhang, Kai Wu, Jiuyin Xu
| BioRxiv
Abstract Prostaglandin E2 (PGE2) signaling through EP2 and EP4 receptors plays a crucial role in inflammation, pain, and cancer progression. Selective and dual antagonists of these receptors have shown promising therapeutic potential. However, the structural basis for their binding modes and selectivity remained unclear.
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