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Jiuying Zhao on Muck Rack

Jiuying Zhao

As seen in: Nature, Journal of Translational Medicine
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Articles

Unraveling the HGF/MET axis in Mallory-Denk body pathogenesis associated with liver fibrosis through single-cell transcriptomics

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By Xiaoping Tang, Yi Shi, Jia Hong Pan, Yi Zhao, Maoping Huang, Huanhou Su, Wanmei Zhou, Xingguang Luo, Xiao Luo, Jinge Zhang, Jiuying Zhao, Jiangtao Jia, Jinru Li, Bei Zhong, Lan Tang, Zhuo Chen, Yongchang Ouyang, Samuel French, Yihui Huang, Xinghua Pan, Hui Liu, Zhichun Dang
| Nature Verified
Abstract Mallory-Denk bodies (MDBs) are protein aggregates commonly observed in chronic liver diseases, including liver fibrosis. However, the intrahepatic crosstalk driving MDB pathogenesis and fibrosis progression remains poorly understood. Using single-nucleus RNA sequencing (snRNA-seq), we identified significant cellular heterogeneity and a distinct hepatocyte subpopulation, termed MDB-associated hepatocytes (MAHs). MAHs were strongly correlated with hepatocellular carcinoma progression.
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TGF-β/JNK axis mediates mitochondrial damage and macrophage cGAS-STING activation in liver Mallory-Denk body pathogenesis - Journal of Translational Medicine

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By Yi Shi, Maoping Huang, Wanmei Zhou, Yi Zhao, Bei Zhong, Samuel French, Xiaoping Tang, Hui Liu, Jiuying Zhao
| Journal of Translational Medicine Verified
Materials and methods Formalin-fixed paraffin-embedded (FFPE) liver biopsies from patients with HCC (n = 10) were obtained from the archives of Qingyuan Affiliated Hospital of Guangzhou Medical University, following Institutional Review Board approval (IRB-2022–094). Cases with significant MDBs (n = 3) were selected and evaluated by experienced pathologists (Table S1). The study adhered to the principles of the Declaration of Helsinki, with data analyzed anonymously.
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