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Jiuyong Xie

As seen in: Nature, BioRxiv
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Articles

Integrating whole genome and transcriptome sequencing to characterize the genetic architecture of isoform variation - Nature Communications

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By Chunyu Liu, Roby Joehanes, Jiuyong Xie, Jian Yang, Mengyao Wang, Tianxiao Huan, Shih-Jen Hwang, Jia Wen, Quan Sun, Nancy L. Heard-Costa, April P. Carson, Laura M. Raffield, Alex P. Reiner, Nora Franceschini, Paul L. Auer, Charles Kooperberg, Yun Li Verified, Joanne M. Murabito
| Nature Verified
Abstract We present a whole-blood isoform ratio QTL (irQTL) resource by analyzing genome-wide isoform-to-gene expression ratios using sequencing data. In Framingham Heart Study (FHS, n = 2622) discovery, we identify over 1.1 million cis-irQTLs (minor allele frequency [MAF] ≥ 0.01, ±1 Mb of 10,883 isoform transcripts, P < 5 × 10−8) across 4,971 genes. Among 11,425 sentinel cis-irQTLs, 72% replicate (P < 1 × 10−4) in the Women’s Health Initiative (WHI; n = 2005).
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5-Aza-Cytidine Enhances Terminal Polyadenylation Site Usage for Full-Length Transcripts in Cells

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By Samuel Ogunsola, Ling Liu, Urmi Das, Jiuyong Xie
| BioRxiv
Abstract As an inhibitor of DNA methyltransferases (DNMT) and anti-cancer drug, the many effects of 5-aza-cytidine (5-azaC) on gene expression remains unknown. Here we show that 5-azaC treatment of cultured pituitary tumour cells increases the relative usage of the genomic terminal exons (GTE) across the transcriptome. This effect is largely achieved by switching mRNA polyadenylation (poly(A)) from proximal sites to the GTE, which have a more optimal poly(A) signal consensus motif.
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Variations of intronic branchpoint motif: identification and functional implications in splicing and disease - Communications Biology

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By Jiuyong Xie, Lili Wang, Ren-Jang Lin
| Nature Verified
Abstract The branchpoint (BP) motif is an essential intronic element for spliceosomal pre-mRNA splicing. In mammals, its sequence composition, distance to the downstream exon, and number of BPs per 3´ splice site are highly variable, unlike the GT/AG dinucleotides at the intron ends.
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