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Role of α7nAChR-NMDAR in sevoflurane-induced memory deficits in the developing rat hippocampus

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By P. R, Yize Li, XiaoHong Tang, JiYing Ao
| PLOS
Detrimental effects of volatile anaesthetics, including sevoflurane, on the structure and function of the developing brain have been reported. The internalization of N-methyl-D-aspartate receptors (NMDARs) contributes to anaesthetic neurotoxicity. Both nicotinic acetylcholine receptors (nAChRs) and NMDAR play a critical role in the development of the nervous system. Moreover, nAChR can interact with NMDAR, and previous studies have demonstrated modulation of NMDAR by nAChR.
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