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RD21 enhances resistance to the strawberry vein banding virus by promoting autophagy‐mediated degradation of the viral silencing suppressor P6 protein
Introduction Autophagy is a mechanism conserved throughout evolution in eukaryotes and involves the degradation and recycling of cytoplasmic materials (He and Klionsky, 2009). This is mainly accomplished through the formation of a double-membrane autophagosome around the material to be degraded, followed by fusion of the autophagosome to a vacuole, within which degradation occurs. The entire process is regulated by a series of autophagy-related genes (ATGs) (Klionsky and Codogno, 2013).
Dexmedetomidine inhibits inflammatory reaction in the hippocampus of septic rats by suppressing NF-κB pathway
Dexmedetomidine (DEX) is known to provide neuroprotective effect in the central nervous system. However, the detailed mechanism remains far more elusive. This study was designed to investigate the relevant mechanisms of DEX's neuroprotective effect. Sprague–Dawley (SD) rats were injected with dexmedetomidine and/or Lipopolysaccharide (LPS) intraperitoneally, and inflammatory cytokines in serum and in the hippocampus were measured by enzyme linked immunosorbent assay (ELISA).
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