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Ji‐Ying Song

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Articles

No relation between docetaxel administration route and high‐grade diarrhea incidence

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By Frederik E Stuurman, Hilde Rosing, Ji‐Ying Song, Jurjen S. Lagas
| Wiley
Abstract Oral administration of docetaxel in combination with the CYP3A4 inhibitor ritonavir is used in clinical trials to improve oral bioavailability of docetaxel. Diarrhea was the most commonly observed and dose‐limiting toxicity. This study combined preclinical and clinical data and investigated incidence, severity and cause of oral docetaxel‐induced diarrhea. In this study, incidence and severity of diarrhea in patients were compared to exposure to orally administered docetaxel.
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