Joangela Nouel on Muck Rack

Joangela Nouel

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The vaccinia virus E3L dsRNA binding protein detects distinct production patterns of exogenous and endogenous dsRNA

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By Wenjing Zhang, Nikhila S Tanneti, Alejandra Fausto, Joangela Nouel
| biorxiv.org
Abstract Double-stranded RNA (dsRNA) is a pathogen associated molecular pattern recognized by multiple pattern recognition receptors and induces innate immune responses. Viral infections can generate dsRNA during virus replication. Genetic mutations can also lead to endogenous dsRNA accumulation. DsRNA is present in multiple conformations such as the A form (A-30 dsRNA) or Z form (Z-dsRNA).
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