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Joanna Bartman on Muck Rack

Joanna Bartman

As seen in: BioRxiv
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Forebrain neuronal SMC3 regulates body weight and metabolic health partially through regulation of hypothalamic Melanocortin 4 receptor

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By Dmitriy Getselter, Nataly Saleev, Joanna Bartman, Roey Gutman
| BioRxiv
Abstract SMC3 is a major component of the cohesin complex that regulates higher-order chromatin organization and gene expression. Mutations in SMC3 gene are found in patients with Cornelia de Lange syndrome (CdLs). This syndrome is characterized by intellectual disabilities, behavioral patterns as self-injury, as well as metabolic dysregulation. Nonetheless, little is known about the role of neuronal SMC3 in gene expression and physiology in adulthood.
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