Joanna Bou Saab on Muck Rack

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Articles

Glibenclamide Prevents Diabetes in NOD Mice

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By Smaragda Lamprianou, Conny Gysemans, Joanna Bou Saab, Helena Pontes
| PLOS
Previous work has revealed that Cx36, the sole connexin expressed in the insulin-producing beta cells, enhances the secretion of insulin, and promotes the resistance of beta cells against pro-inflammatory cytokines. In parallel, the anti-diabetic sulphonylurea glibenclamide was shown to promote the assembly and function of Cx36 channels. Here, we assessed whether glibenclamide could protect the insulin-producing cells against conditions mimicking those expected at the onset of type 1 diabetes.
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