Joanna Ida Sulkowska

Abstract Knots and lasso topology represent a class of natural motifs found in proteins which are characterized by a threaded structure. Proteins with a lasso motif represent a macroscopic version of the peptide lasso, which are known for their high stability and offer tremendous potential for the development of novel therapeutics. Here, based on AlphaFold, we have shown the limit of topological complexity of naturally occurring protein structures with cysteine bridges.