Joaquín Barroso-Flores

Abstract Methyl groups play a vital role in pharmaceuticals, where their installation onto aryl and heteroaryl moieties of drug candidates can often enhance drug-target interactions. This phenomenon, termed the “magic methyl effect”, has become an important tool for improving therapeutic potency during the lead optimization stages of drug development.

Abstract The Grignard reaction represents one of the most powerful carbon-carbon bond forming reactions and is the subject of continual study. Investigations of alkyl magnesium halide additions to β-hydroxy ketones identified a unique effect of the magnesium halide on diastereoselectivity, with alkylmagnesium iodide reagents demonstrating high levels of selectivity for the formation of 1,3-syn diols.

The current global economy heavily relies on digital and data-based technologies, which have the use of supercomputing at their core. Latin America is a vast source of human talent in computer science, but the lag in infrastructure investment due to economic and political struggles may cause the economic development of the region to fall behind. Computer science lies at the center of the twenty-first century zeitgeist.