INTRODUCTION Childhood-onset systemic lupus erythematosus (cSLE) is a chronic, multisystemic, autoimmune disease diagnosed before 18 years of age.1 Those with cSLE are at an increased risk for depressive, fatigue, and pain symptoms,1, 2 which are associated with lower health-related quality of life (HRQoL) even when disease activity is well controlled.3 Female youth, as well as Asian, Native American, and Black youth, are disproportionately impacted by cSLE.4 Indeed, cSLE is the fifth leading...