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Jochen HM Prehn

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Articles

Androgen receptor localisation and protein interactions provide insight into steroid mediated metabolic shifts in endocrine resistant breast cancer

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By Rachel Bleach, Emir Bozkurt, Jingqi Xin, Katherine Sheehan, Sally L. Shirran, Stephanie Agbana, Mihaela Ola, Leonie S. Young, Nicole S. Spoelstra, Jennifer K. Richer, Ana Vargas, Leonard D. Goldstein, Christine Chaffer, Michael W. O’Reilly, Marie McIlroy, Heloisa H. Milloli, Jochen HM Prehn
| Nature Verified
Abstract Aromatase inhibitors (AI) are standard therapy for hormone receptor–positive breast cancer in post-menopausal women, yet recurrence remains common. Our previous work suggests that an androgen‑dominated steroid environment may drive AI resistance. Although most androgen research has focused on classical genomic pathways in reproductive tissues, interest is growing in their non‑reproductive functions.
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