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Jodi Barnard

As seen in: Nature
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Articles

Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress

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By Aitana Martinez-Cotrina, Yanling Hu, Rhys Anderson, Sebastien Janel, Jiin Byun, Daniel Solomon, Juan Alcalde, Frank Lafont, Marc-David Ruepp, Frank Hirth, Bart Tummers, Yong-Yeon Cho, Gian De Nicola, Sarah Mizielinska, Manolis Fanto, Rebecca Casterton, Jodi Barnard, Eleanor Wycherley
| Nature Verified
Abstract Neurodegenerative diseases are frequently associated with proteotoxic stress linked to disease specific proteins. The autophagy-lysosome system provides essential control of proteotoxic stress and its failure can lead to initiation of apoptosis. However, in aging and neurodegenerative diseases apoptosis is insufficient to account for all neuronal death, and several different cell death types have been reported in these contexts.
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