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Abstract FOXG1 syndrome is a severe neurodevelopmental disorder characterized by microcephaly, profound intellectual disability with communication deficits including lack of speech, impaired social interaction, increased anxiety, hyperkinetic/dyskinetic movements, seizures and abnormal sleep patterns. Mutations in a single allele of the FOXG1 gene cause disease, likely due to loss-of-function.
Figure S5RNA-Sequencing in Fmr1 KO Neurons Treated with JQ1 and THZ, Related to Figure 5(A) Overlap of JQ1 regulated genes in WT and KO neurons.(B) Western blot of Brd4 target genes (that are decreased by JQ1), FMRP target proteins (that are not affected by JQ1), and histone modifications (some of which are affected by JQ1.)(C–F) qRT-PCR for WT and KO neurons treated with JQ1 for Nr4a1 (C), Shank2 (D), Arc (E), and Gria1 (F).
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