Joe Nabarro

Results and Discussion Click to copy section linkSection link copied! Our initial project design was inspired by the work of the Hamachi group, who over the past 15 years have pioneered the development of both ligand-directed chemistries and proximity catalysis. (5,15,16) Of the catalyst systems reported, we were particularly attracted to the use of pyridinium oximes, which can catalyze protein acylation with N -acyl- N -alkylsulfonamide (NASA) reagents in a proximity-dependent manner.

Abstract The Gram-negative bacterial cell envelope is defined by an asymmetric outer membrane where the outer leaflet adopts a highly ordered structure composed principally of lipopolysaccharide molecules. The organisation and dynamics of these glycolipids are key to the ability of the outer membrane to act as an innate barrier against chemical and antibiotic challenges, and as a load bearing element for the cell.