Jofre Font-Mateu

New Results doi: https://doi.org/10.1101/2023.05.14.540708 Abstract In hormone-responsive breast cancer cells, progesterone (P4) has been shown to act via its nuclear receptor (PR), a ligand-activated transcription factor. A small fraction of PR is palmitoylated and anchored to the cell membrane (mbPR) forming a complex with estrogen receptor alpha (ERα).

An early event in reprogramming of somatic nuclei transplanted into oocytes is the binding to chromatin of the oocyte specific linker histones H17,19,20,21,22. In this regard, incubation of somatic nuclei prepared from Drosophila S2 cells in DREX, which is enriched in dBigH1, resulted in its incorporation to chromatin. Immunofluorescence analyses (IF) showed a clear association of dBigH1 with S2 nuclei after incubation in DREX (Fig. S1a).