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Johannes Bargehr

As seen in: Nature, Stem Cell Reports
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Articles

Epicardially secreted fibronectin drives cardiomyocyte maturation in 3D-engineered heart tissues

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By Lay Ping Ong, Puddicombe Way, Johannes Bargehr
| Stem Cell Reports Verified
Introduction The global burden of heart failure is reflected by an estimated 37.7 million patients, of whom 50% will not survive the 5 years following their diagnosis ( ; Zarrinkoub et al., 2013 Zarrinkoub R. Wettermark B. Wändell P. Mejhert M. Szulkin R. Ljunggren G. Kahan T. The epidemiology of heart failure, based on data for 2.1 million inhabitants in Sweden. ). A large proportion of heart failure is due to ischemic myocardial injury resulting in loss of contractile working myocardium.
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FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2 - Nature

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By Teresa Brevini, Mailis Maes, Lu Wang, Marnie L. Brown, Jo Tutchener Sharp, Megan Neary, Lee M. Tatham, James Stewart, Mahnaz Darvish-Damavandi, Thomas Williams, Johannes Bargehr, Sanjay Sinha, Kourosh Saeb-Parsy, Axel Wester, Espen Melum, Chloe Bramwell, Eleanor J. Barnes, Andrew Moon, Ravindra K Gupta, Stephen Baker, Anthony Davenport, Vassilis G. Gorgoulis, Joo-Hyeon Lee, Nicholas J Matheson, Michael Trauner, Andrew Fisher, Christopher Watson, Andrew Owen, Ludovic Vallier
| Nature Verified
Author notes These authors jointly supervised this work: Ludovic Vallier; Fotios Sampaziotis Authors and Affiliations Wellcome – MRC Cambridge Stem Cell Institute, Cambridge, UK Teresa Brevini, Stephanie Brown, Scott Dillon, Sagar S. Varankar, Mahnaz Darvish-Damavandi, James A. Heslop, Davide Rossetti, Olivia C. Tysoe, Vasileios Galanakis, Marta Vila-Gonzalez, Johannes Bargehr, Sanjay Sinha, Darran Clements, Peter Humphreys, Simon J. A.
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Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration

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By Johannes Bargehr, Lay Ping Ong, Alessandro Bertero, Charles E. Murry
| Nature Verified
Abstract The epicardium and its derivatives provide trophic and structural support for the developing and adult heart. Here we tested the ability of human embryonic stem cell (hESC)-derived epicardium to augment the structure and function of engineered heart tissue in vitro and to improve efficacy of hESC-cardiomyocyte grafts in infarcted athymic rat hearts.
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