John Barton
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Clonal heterogeneity and antigenic stimulation shape persistence of the latent reservoir of HIV
Factors underlying long-term LR persistence. Despite suppressive ART, the latent reservoir persists for decades in HIV-1-infected individuals. How do different components of the LR contribute to its persistence? We find that the presence of large latent clones is the most important factor in the long-term persistence of the latent reservoir, despite their low probabilities of reactivation. In fact, small pr allows these clones to grow to large sizes with minimal decay due to reactivation (Fig 4A).
In Loving Memory Of: A Sonnet by John Barton
To live is the rarest thing in the world. Most people exist, that is all.
Notes on Digging a Hole
A A A While renovating their Edmonton house, writer Zachary Ayotte and his partner discover water—“Just moisture… Like oil across a teenaged forehead”—seeping into their basement.
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