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John D. E. Barks on Muck Rack

John D. E. Barks

As seen in: Nature
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Articles

Comparing neuroprotective drug efficacy in rodent neonatal brain injury models

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By Yiqing Liu, Julie Sturza, Niko Kaciroti, William J. Meurer, Faye Silverstein, John D. E. Barks
| Nature Verified
Abstract A challenge in preclinical neonatal neuroprotection research is the implementation of study designs that enable direct comparison of multiple potentially effective drugs. We used adaptive design to test four FDA-approved drugs (azithromycin, erythropoietin, caffeine, and melatonin) concurrently and determine which best combined safety and efficacy.
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