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Articles by John Dulos
Adoptive cell therapy with macrophage-drug conjugates facilitates cytotoxic drug transfer and immune activation in glioblastoma models
Editor’s summary Glioblastoma remains the most common and aggressive adult primary brain tumor with limited effective therapies. Macrophages are key players in the glioblastoma immunosuppressive microenvironment and have the ability to infiltrate these solid tumors and interact with glioma cells. Here, Sun et al. developed an adoptive cell therapy of allogeneic macrophages loaded with ferritin-drug conjugates to deliver therapeutic payloads to glioblastoma cells.
Microglial pruning of glycinergic synapses disinhibits spinal PKCγ interneurons to drive pain hypersensitivity in mice
Editor’s summary Peripheral nerve injury can lead to allodynia, a pain sensation evoked by innocuous stimuli. A disinhibition of spinal PKCγ interneurons (INs), which receive input from low-threshold mechanoreceptors but project to nociceptive circuits, is involved in the development of allodynia, but what mediates these circuit adaptations is not completely understood. Here, Zou et al.
Vaccines combining slow release and follicle targeting of antigens increase germinal center B cell diversity and clonal expansion
Editor’s summary A great deal of research has aimed to improve immunogens for vaccines. However, improving immunogens alone will not necessarily result in a successful vaccine. Here, Rodrigues and Zhang et al. focused on the other half of the vaccine, the adjuvant.
ADAMTS-5 inhibition reduces muscle inflammation and fibrosis and improves function in mouse models of Duchenne muscular dystrophy
Editor’s summary In Duchenne muscular dystrophy (DMD), dysregulated provisional matrix synthesis and proteolysis can exacerbate disease pathology. Here, Dulos and colleagues tested whether inhibition of A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), which is up-regulated in the serum of patients with DMD, with the small-molecule inhibitor GLPG1972 could reduce inflammation and fibrosis and improve contractile function in two mouse models of the disease.
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