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John FX Diffley on Muck Rack

John FX Diffley

As seen in: BioRxiv
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Articles

Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication

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By Masashi Minamino, John FX Diffley, Frank Uhlmann
| BioRxiv
Abstract Concomitant with DNA replication, the ring-shaped cohesin complex encircles both newly synthesized sister chromatids, enabling their faithful segregation during cell divisions. Our molecular understanding of how cohesin co-entraps both replication products remains incomplete. Here, we reconstitute sister chromatid cohesion establishment using purified budding yeast proteins.
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Replisome passage through the cohesin ring

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By Maxim I. Molodtsov, Frank Uhlmann, Samson Glaser, John FX Diffley
| BioRxiv
Abstract Following eukaryotic genome replication, the two newly synthesised sister chromatids remain paired by the ring-shaped cohesin complex, enabling their faithful segregation to daughter cells during cell divisions. Cohesin topologically embraces DNA already before DNA replication, and replisome passage through the cohesin ring is thought of as a fail-safe mechanism ensuring that cohesin entraps both replication products. Whether replisomes indeed pass through cohesin rings remains unknown.
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