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Articles by John J.P
Proprotein convertase subtilisin/kexin type 9: from... : Current Opinion in Cardiology
Article Keywords Keywords drug development, genetics, proprotein convertase subtilisin/kexin type 9 inhibitors, prevention
Effect of alirocumab dose increase on LDL lowering and... : Coronary Artery Disease
Introduction Current guidelines for the management of hypercholesterolemia acknowledge that, although most patients achieve sufficient reduction in LDL cholesterol (LDL-C) levels with high-dose statin therapy, a proportion of patients may require the addition of a nonstatin lipid-lowering therapy (LLT) 1–4.
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
CANTOS was designed to test directly the inflammatory hypothesis of atherothrombosis. In this trial, in patients with a history of myocardial infarction, the levels of high-sensitivity C-reactive protein and interleukin-6 were significantly reduced from baseline by canakinumab, as compared with placebo, with no significant reduction in lipid levels from baseline.
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
29 References 3323 Citing Articles Letters Abstract Background Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events. Since statins lower levels of high-sensitivity C-reactive protein as well as cholesterol, we hypothesized that people with elevated high-sensitivity C-reactive protein levels but without hyperlipidemia might benefit from statin treatment.
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
Introduction Current treatment algorithms for the prevention of myocardial infarction, stroke, and death from cardiovascular causes recommend statin therapy for patients with established vascular disease, diabetes, and overt hyperlipidemia.1,2 However, half of all myocardial infarctions and strokes occur among apparently healthy men and women with levels of low-density lipoprotein (LDL) cholesterol that are below currently recommended thresholds for treatment.
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