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John Maina Ngundu on Muck Rack

John Maina Ngundu

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Articles

Mechanistic Studies of the Multiple Myeloma and Melanoma Cell-Selective Toxicity of the Rpn13-Binding Peptoid KDT-11

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By Paige Dickson, Scott Simanski, Thomas Kodadek, John Maina Ngundu
| Cell Chemical Biology Verified
Highlights • Peptidomimetic KDT-11 induces cancer-selective G1/S cell-cycle arrest • KDT-11 does not disrupt its reported target Rpn13's known protein interactions • Cellular sensitivity to KDT-11 does not relate to Rpn13 protein level Summary We previously reported a peptoid ligand for the proteasomal ubiquitin receptor Rpn13 called KDT-11 and demonstrated that this compound is toxic to multiple myeloma cells, but not non-malignant cells.
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