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John-Peder Escobar Kvitting on Muck Rack

John-Peder Escobar Kvitting

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Role of valve endothelial cells and extracellular vesicles in aortic valve calcification in vitro

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By Arkady Rutkovskiy, Krizia Sagini, Hanne Haslene-Hox, Maria Bogdanova, Alicia Llorente, Kåre-Olav Stensløkken, Jarle Vaage, Daria Evensen, Arsenii Zabirnyk, John-Peder Escobar Kvitting, Mari-Liis Kaljusto
| Nature Verified
Abstract Aortic valve calcification is mediated by valve interstitial cells (VICs). We hypothesized that valve endothelial cells (VECs) stimulate pro-osteogenic changes in VICs, potentially via extracellular vesicles (EVs). We investigated VECs' pro-osteogenic effects on VICs, compared proteomes of healthy versus calcified VECs, and examined VECs-derived EVs effects on calcification. Human VECs and VICs were co-cultured in 2D and 3D (collagen gel) formats with osteogenic induction.
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