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john spencer

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Articles

Targeting the p53 cancer mutants Y220C, Y220N, and Y220S with the small-molecule stabilizer rezatapopt - Cell Death & Disease

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By Danai Mavridi, Julianne Funk, Dimitrios-Ilias Balourdas, Oleg Timofeev, john spencer, Thorsten Stiewe, Andreas C. Joerger, Raysa Khan Tareque
| Nature Verified
Abstract The cavity-creating p53 cancer mutation Y220C, which accounts for an estimated 125,000 new cancer cases per year, serves as an excellent paradigm for the development of mutant p53 reactivators. Several molecules that reactivate this thermolabile cancer mutant by targeting the mutation-induced crevice have been developed, and one of them, rezatapopt, is currently in clinical trials.
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John Spencer: UN’s Gaza commission distorts meaning of 'genocide' Original

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By john spencer
| National Post Verified
Advertisement 1 Report erases realities of urban warfare Article content Urban warfare is the most unforgiving form of combat. It is not fought by tank columns maneuvering across open deserts, but by small units clearing building to building, block to block, tunnel to tunnel. This is the reality facing Israel’s soldiers today.
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The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells - Nature Communications

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By Robert Zach, Sandra M. Martín-Guerrero, Abdulrahman A. Alatawi, Kim Hou Chia, Alex Herbert, Ryan West, john spencer, Thomas Hunt, David Andrews, Pedro R. Cutillas, Antony Oliver, Simon Ward Verified
| Nature Verified
Abstract The Greatwall kinase inhibits PP2A-B55 phosphatase activity during mitosis to stabilise critical Cdk1-driven mitotic phosphorylation. Although Greatwall represents a potential oncogene and prospective therapeutic target, our understanding of the cellular and molecular consequences of chemical Greatwall inactivation remains limited.
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