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John Weroha on Muck Rack

John Weroha

As seen in: Nature
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Articles

Nuclear cathepsin L induces DNA damage by regulating DNA repair factors in ovarian cancer

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By Prabhu Thirusangu, Upasana Ray, Ling Jin, Biswajit das, Christopher Pathoulas, Julie Cadwallader Staub, Ann L. Oberg, Xiaonan Hou, Nagarajan Kannan, Jamie Bakkum-Gamez, Viji Shridhar, Jamison L. VanBlaricom, John Weroha
| Nature Verified
Abstract Resistance to PARP inhibitors (PARPi) remains a major clinical challenge in ovarian cancer (OC), emphasizing the need for novel strategies to enhance therapeutic efficiency. Our previous work revealed that the antimalarial drug quinacrine (QC) can be repurposed to induce cell death in OC by promoting lysosomal release of active cathepsin L (CTSL).
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