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Johne Liu on Muck Rack

Johne Liu

As seen in: BioRxiv
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Articles

Engineered spermidine-secreting Saccharomyces boulardii ameliorate colitis and colon cancer in mice

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By Roger Palou, Ruizhen Li, Guijun Zhang, Johne Liu
| BioRxiv
Abstract Experimental studies suggest that the probiotic yeast Saccharomyces boulardii can mitigate the symptoms of inflammatory bowel disease. However, these results are equivocal and S boulardii probiotic therapy has not gained widespread acceptance in clinical practice. To assess whether the therapeutic properties of S boulardii might be improved upon, we engineered S boulardii to overproduce and secrete spermidine, a pro-regenerative natural metabolite.
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