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Joji Nagasaki

As seen in: Nature, Wiley Online Library, Cell Reports
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Articles by Joji Nagasaki

Liver-specific amino acid metabolism impacts on efficacy of cancer immunotherapy

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By Fumiaki Mukohara, Youki Ueda, Hiroaki Kanzaki, Sadahisa Ogasawara, Jason Lin, Masahito Kawazu, Toshifumi Ninomiya, Naoya Kemmotsu, Joji Nagasaki, Shinichi Toyooka, Tsuyoshi Osawa, Takamasa Ishino, Yosuke Togashi, Yuma Fukumoto, Momoko Iwatsuru
| Nature Verified
Abstract The combination immunotherapies, including those with atezolizumab and bevacizumab (Atez/Bev), have become standard therapy for hepatocellular carcinoma (HCC). However, its efficacy remains limited and reliable biomarkers are lacking.
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Combination therapy with hydrogen peroxide and irradiation promotes an abscopal effect in mouse models

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By Li Zhu, Joji Nagasaki, Yoshihiro Otani, Naoya Kemmotsu
| Wiley Online Library Verified
ORIGINAL ARTICLE Naoya Kemmotsu and Li Zhu contributed equally to this work. Abstract Hydrogen peroxide (H2O2) induces oxidative stress and cytotoxicity, and can be used for treating cancers in combination with radiotherapy. A product comprising H2O2 and sodium hyaluronate has been developed as a radiosensitizer. However, the effects of H2O2 on antitumor immunity remain unclear.
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PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes

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By Joji Nagasaki, Osaka City, Takashi Inozume, Nicolas Sax
| Cell Reports Verified
Highlights • The tumor microenvironment has both skewed Tex and Tnon-ex clonotypes • Among skewed clonotypes, Tex, but not Tnon-ex, directly attack tumor cells • PD-1 blockade promotes Tex clonotype infiltration • TDLNs can be the origin of such Tex clonotypes Summary PD-1 blockade exerts clinical efficacy against various types of cancer by reinvigorating T cells that directly attack tumor cells (tumor-specific T cells) in the tumor microenvironment (TME), and tumor-infiltrating lymphocytes...
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