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Jomy Kuruvila on Muck Rack

Jomy Kuruvila

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Articles

Immunopeptidome analysis reveals SERPINB3 as an autoantigen driving eczematized psoriasis

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By Manja Jargosch, Emanuele Scala, Johannes Grosch, Jomy Kuruvila
| Science Magazine Verified
Abstract Psoriasis (Pso) is a chronic inflammatory skin disease driven by T helper 17 (TH17) cells, with several clinical subtypes. While self-reactive immune responses have been observed, the role of autoantigens in Pso remains unclear. Using immunopeptidomics, we identified serpin family B member 3 (SERPINB3) and SERPINB4 as candidate autoantigens in Pso skin.
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