Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Jonas Bergquist
Proteomic signatures in cerebrospinal fluid and their clinical associations in patients with ME/CFS
Abstract This study evaluated the cerebrospinal fluid (CSF) proteomes from 31 patients diagnosed with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We quantified 902 proteins, each expressed in at least eleven samples, and systematically categorized clinical factors relevant to ME/CFS symptoms—including autonomic dysfunction, neuroinflammation and metabolic disturbances.
Vården vid ME/CFS och postcovid får inte bygga på hypoteser
Sten Helmfrid docent, fysik; medlem, Riksförbundet för ME-patienter Kerstin Heiling leg psykolog, fil dr; f d förbundsordförande, Riksförbundet för ME-patienter Jonas Bergquist professor, analytisk kemi/neurokemi, Uppsala universitet Anders Rosén professor emeritus, Linköpings universitet Per Julin med dr, överläkare, Karolinska universitetssjukhuset Huddinge Bo Christer Bertilson docent, allmänmedicin, Bragée kliniker, Karolinska institutet Per Sjögren fil dr, Bragée kliniker Judith...
Plasma proteomic profile reveals persistent immune activation in post-acute sequelae of SARS-CoV-2 infection
Abstract Plasma proteomic profiling of 92 individuals with Post-Acute Sequelae of SARS-CoV-2 infection (PASC), assessed a mean of 34 months after acute infection, revealed a distinct inflammatory signature. Using proximity extension assay technology, 358 proteins were quantified, identifying 26 differentially expressed proteins (DEPs) in PASC: 23 upregulated and 3 downregulated. The most upregulated proteins were Oncostatin M (OSM) and IL-1 receptor antagonist (IL1RN).
Special Issue on the 18th Nordic Mass Spectrometry Meeting in Geilo, Norway
EDITORIAL Special Issue on the 18th Nordic Mass Spectrometry Meeting in Geilo, Norway Léon Reubsaet, Corresponding Author Léon Reubsaet Section of Pharmaceutical Chemistry, Department of Pharmacy, University of Oslo, Oslo, Norway Correspondence: Léon Reubsaet (leonr@farmasi.uio.no) Jonas Bergquist (jonas.bergquist@kemi.uu.se) Search for more papers by this authorJonas Bergquist, Corresponding Author Jonas Bergquist Analytical Chemistry, Department of Chemistry BMC, Uppsala University,...
ME/CFS och postcovid bör inte klassas som funktionella tillstånd
Sten Helmfrid docent, fysik; medlem, Riksförbundet för ME-patienter Kerstin Heiling leg psykolog, fil dr; f d förbundsordförande, Riksförbundet för ME-patienter Jonas Bergquist professor, analytisk kemi/neurokemi, Uppsala universitet Anders Rosén professor emeritus, Linköpings universitet Per Julin med dr, överläkare, Karolinska universitetssjukhuset Huddinge Bo Christer Bertilson docent, allmänmedicin, Bragée kliniker, Karolinska institutet Per Sjögren fil dr, Bragée kliniker Judith...
Radionuclide Production : Increasing Availability Through Automation
Nyckelord: Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry; Sammanfattning: Access to radionuclides is critical for the development and clinical application of radiotracers. However, their production, separation, and characterization can be complex and labor intensive. This poses a challenge as the demand for radionuclides is rapidly increasing, and limited access will slow research and their adoption into the clinics.
Steroid dynamics in myalgic encephalomyelitis / chronic fatigue syndrome: a case-control study using ultra performance supercritical fluid chromatography tandem mass spectrometry | Journal of Translational Medicine | Full Text
No significant differences in absolute steroid levels were observed between the ME/CFS and control groups, either in the combined cohort or within gender-stratified groups. However, this may reflect limited statistical power rather than the absence of true biological differences. To explore this, we estimated the sample sizes required to detect the effects sizes (Cohen’s d) derived from the present dataset (Table 2) using a significance threshold of α = 0.05 and a statistical power of 0.80.
Quantitative Bioanalysis : Liquid separations coupled to targeted mass spectrometric measurements of bioactive compounds
Nyckelord: NATURAL SCIENCES; NATURVETENSKAP; Analytical chemistry; Method development; Enhanced microdialysis; Column switching; Liquid chromatography; Capillary electrophoresis; Electrospray ionization; Mass spectrometry; Triple quadrupole; Time-of-flight; Quantitation; Validation; Analytisk kemi; Sammanfattning: Performing quantitative analysis of targeted bioactive compounds in biological samples, such as blood plasma, cerebrospinal fluid or extracts from pig liver, put high demands on the...
Proteomic Profiling of Inflammation Following Traumatic Brain Injury and Cerebral Insults : Decoding Molecular Signatures for Therapeutic Insights
Nyckelord: MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomarkers; encephalitis; mass-spectrometry; microdialysis; neuroinflammation; neurointensive care; proteomics; proximity extension assay; traumatic brain; Sammanfattning: Traumatic brain injury (TBI) is a complex and diverse condition influenced by various factors, all of which contribute to a wide range of outcomes for the patients.
Searching for Paralytic Toxin, Tetrodotoxin, in Swedish Bivalve Shellfish
Choose an area of interest and we will send you notifications of new preprints at your preferred frequency.
A multi-tissue longitudinal proteomics study to evaluate the suitability of post-mortem samples for pathophysiological research - Communications Biology
Abstract Recent developments in mass spectrometry-based proteomics have established it as a robust tool for system-wide analyses essential for pathophysiological research. While post-mortem samples are a critical source for these studies, our understanding of how body decomposition influences the proteome remains limited.
Three cases with chronic obsessive compulsive disorder report gains in wellbeing and function following rituximab treatment - Molecular Psychiatry
Abstract Immunological aetiology is supported for a subgroup with obsessive compulsive disorder (OCD) and conceptualized as autoimmune OCD. The longitudinal clinical course is detailed for three severely ill cases with OCD and indications of immunological involvement with off-label rituximab treatment every six months. All cases showed clear and sustained gains regarding symptom burden and function for over 2.5 years.
Untargeted Metabolomics and Quantitative Analysis of Tryptophan Metabolites in Myalgic Encephalomyelitis Patients and Healthy Volunteers: A Comparative Study Using High-Resolution Mass Spectrometry
1. Introduction Click to copy section linkSection link copied! Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disorder. Symptoms of the condition range from mild to severe, with the most severely affected individuals enduring ongoing fatigue, frequent pain, and postexertional malaise (PEM), which is the exacerbation and onset of new symptoms after exertion, both physical and mental.
AVHANDLINGAR.SE: Exploring the role of tryptophan metabolites in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) : Development and application of high resolution mass spectrometry methods
Nyckelord: NATURVETENSKAP; NATURAL SCIENCES; Myalgic encephalomyelitis chronic fatigue syndrome ME CFS ; liquid chromatography; high-resolution mass spectrometry; tryptophan metabolites; kynurenine; serotonin; neuroprotective compounds; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry; Sammanfattning: Myalgic encephalitis/chronic fatigue syndrome (ME/CFS) is a severe systemic disorder characterized by neurological, gastrointestinal, inflammatory...
Elevated Plasma Levels of Arginines During Labor Among Women with Spontaneous Preterm Birth: A Prospective Cohort Study
1 Introduction Preterm birth (PTB), birth before gestational week 37, is a leading cause of infant mortality and morbidity [1]. In addition to causing one million deaths globally each year, PTBs are associated with long-term complications, including impaired neurodevelopment, lung disease and adverse cardiovascular effects [1]. The frequency of PTB varies globally but is estimated to be approximately 11% worldwide [2].
Multi-omics analysis of aggregative multicellularity
Abstract The extent to which mRNA and protein levels or their regulation correlate remains obscure, especially during development. In particular, this is true for organisms that exhibit aggregative multicellularity, such as the social amoeba Dictyostelium discoideum. The transcriptome of D.
Analysis of tryptophan metabolites and related compounds in human and murine tissue: development and validation of a quantitative and semi-quantitative method using high resolution mass spectrometry
Analysis of tryptophan metabolites and related compounds in human and murine tissue: development and validation of a quantitative and semi-quantitative method using high resolution mass spectrometry† This study explores the metabolic differences between human and murine plasma in addition to differences between murine subcutaneous and visceral white adipose tissue. A quantitative and semi-quantitative targeted method was developed and validated for this purpose.
The Combination of Quantitative Proteomics and Systems Genetics Analysis Reveals that PTN Is Associated with Sleep-Loss-Induced Cognitive Impairment
The Combination of Quantitative Proteomics and Systems Genetics Analysis Reveals that PTN Is Associated with Sleep-Loss-Induced Cognitive Impairment | Journal of Proteome Research
Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth
1 INTRODUCTION About 85%–95% of all births occur at term.1 Term birth is defined as birth on gestational weeks 37 + 0 to 41 + 6.2 According to the latest report from The Swedish National Board of Social Affairs and Health, about 75% of all vaginal births start spontaneously and the remaining 25% after induction of labor.3 Further, about 18% of all births occur by cesarean section and 8% of all births are by elective cesarean section (ECS).3 Labor involves increased uterine contractility,...
Toxins | Free Full-Text | LC-MS/MS Analysis of Cyanotoxins in Bivalve Mollusks-Method Development, Validation and First Evidence of Occurrence of Nodularin in Mussels (Mytilus edulis) and Oysters (Magallana gigas) from the West Coast of Sweden
Abstract : In this paper, an LC-MS/MS method for the simultaneous identification and quantification of cyanotoxins with hydrophilic and lipophilic properties in edible bivalves is presented. The method includes 17 cyanotoxins comprising 13 microcystins (MCs), nodularin (NOD), anatoxin-a (ATX-a), homoanatoxin (h-ATX) and cylindrospermopsin (CYN).
Hyperandrogenic Symptoms Are a Persistent Suffering in Midlife Women with PCOS; a Prospective Cohort Study in Sweden
Abstract : Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women, and the majority suffers from hyperandrogenism. Hyperandrogenism causes psychological morbidity and impaired quality of life in women with PCOS during the reproductive years, but data on prevalence and impact during midlife are lacking. Thus, this study aimed to address whether hyperandrogenism persists into midlife and, if so, what impact it has on quality of life.
Character and environmental lability of cyanobacteria‐derived dissolved organic matter
Abstract Autotrophic dissolved organic matter (DOM) is central to the carbon biogeochemistry of aquatic systems, and the full complexity of autotrophic DOM has not been extensively studied, particularly by high‐resolution mass spectrometry (HRMS).
Complexity of dissolved organic matter in the molecular size dimension: insights from coupled size exclusion chromatography electrospray ionisation mass spectrometry
This article is Open Access Please wait while we load your content... Something went wrong. Try again?
Qualitative analysis of antibody-drug conjugates (ADCs): an experimental comparison of analytical techniques of cysteine-linked ADCs
Antibody-drug conjugates (ADCs) are an emerging type of biotherapeutics. Consisting of an antibody conjugated to small drug molecules through a variety of linkers, this type of therapeutics is challenging to analyse. Several different linker designs, to limit the release of the cytotoxic drug to as close in proximity to the tumour as possible, and multiple variations of tissue specific antibodies sum up to a chemically very complex set of analytes.
A novel, fast and sensitive supercritical fluid chromatography-tandem mass spectrometry (SFC-MS/MS) method for analysis of arachidonic acid metabolites
The development of a rapid, sensitive and reliable method for the quantification of bioactive arachidonic acid metabolites (AA-metabolites) in biological samples is quite challenging due to the minute concentrations, short half-life and their structural complexity arising from different isomers.
The proteome of perilymph in patients with vestibular schwannoma. A possibility to identify biomarkers for tumor associated hearing loss?
The proteome of perilymph in patients with vestibular schwannoma has an inter-individual stable section. However, even in a cohort with homogenous disease, the variation between individuals represented the majority of the detected proteins. Alpha-2-HS-glycoprotein, P02765, was shown to be an independent variable for tumor-associated hearing loss, a finding that needs to be verified in other studies.
Online HPLC-ESI-HRMS Method for the Analysis and Comparison of Different Dissolved Organic Matter Samples
Natural dissolved organic matter (DOM) is an ultracomplex mixture that is essential to global carbon cycling but is poorly understood because of its complexity. The most powerful tool for the DOM characterization is high-resolution mass spectrometry (HRMS) generally combined to direct infusion (DI) as sample introduction.
Effect of mobile phase composition in analysis of aggregates of antibody drug conjugates (ADCs) using size exclusion chromatography
R. Neupane, M. Källsten, F. Lehmann and J. Bergquist, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY02696J If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using RightsLink. Go to our Instructions for using RightsLink page for details.
Effect of mobile phase composition on the analysis of aggregates of antibody drug conjugates (ADCs) using size exclusion chromatography
R. Neupane, M. Källsten, F. Lehmann and J. Bergquist, Anal. Methods, 2018, Advance Article , DOI: 10.1039/C7AY02696J If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using RightsLink. Go to our Instructions for using RightsLink page for details.
Mechanistic investigation of the on-surface enzymatic digestion (oSED) protein adsorption detection method using targeted mass spectrometry
This paper describes an effort to study some of the mechanistic aspects of the earlier established on-surface enzymatic digestion (oSED) method. In a multitude of application areas, it has become important to be able to fully characterize and understand the selective protein adsorption to biomaterial surfaces. Those applications can be in for example biomedicine (implants etc.), in nanotechnology (microchip surfaces and sensors) and in material sciences.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Jonas
Contact Jonas, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack