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Jonathan Huggins

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Articles

Robust discovery of mutational signatures using power posteriors

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By Catherine Xue, Jeffrey Miller, Scott Carter, Jonathan Huggins
| BioRxiv
Abstract Mutational processes, such as the molecular effects of carcinogenic agents or defective DNA repair mechanisms, are known to produce different mutation types with characteristic frequency profiles, referred to as mutational signatures. Non-negative matrix factorization (NMF) has successfully been used to discover many mutational signatures, yielding novel insights into cancer etiology and targeted therapies.
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Effects of antimicrobial therapy duration and class on risk of antimicrobial‐resistant Gram‐negative bacillus bloodstream infection in patients with AML

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By Jonathan Huggins, Ian Barnett, Michael David, Bixby DL
| Wiley Online Library Verified
DATA AVAILABILITY STATEMENT The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
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F1000Research Article: The feasibility of targeted test-trace-isolate for the control of SARS-CoV-2 variants.

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By William Bradshaw, Jonathan Huggins, Alun Lloyd, Kevin Esvelt
| F1000Research
Home Browse The feasibility of targeted test-trace-isolate for the control of... Bradshaw W, Huggins J, Lloyd A and Esvelt K. The feasibility of targeted test-trace-isolate for the control of SARS-CoV-2 variants [version 1; peer review: awaiting peer review]. F1000Research 2021, 10:291 (https://doi.org/10.12688/f1000research.51164.1) NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. All fields are required.
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