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Articles by Jonathan Piscitelli
The GHKL ATPase Family as a Paradigm for MutL Homolog Function in DNA Mismatch Repair
This version is not peer-reviewed. Jonathan M. Piscitelli,Carol M. Manhart * Jonathan M. Piscitelli,Carol M. Manhart * Submitted: 28 October 2025 You are already at the latest version ATP hydrolysis drives essential processes across biology, from nucleic acid translocation and conformational switching to signal transduction.
The Mlh1-Pms1 endonuclease uses ATP to preserve DNA discontinuities as strand discrimination signals to facilitate mismatch repair
Abstract In eukaryotic post-replicative mismatch repair, MutS homologs (MSH) detect mismatches and recruit MLH complexes to nick the newly replicated DNA strand upon activation by the replication processivity clamp, PCNA. This incision enables mismatch removal and DNA repair. Biasing MLH endonuclease activity to the newly replicated DNA strand is crucial for repair.
Rock & Read 5K: Run for your library
By Addie Holby | July 24, 2015 Views: The 6th Annual Rock & Read 5K is set for September 19, 2015 in Plaza Midwood. What is the R&R5K, you ask? It’s a small community race full of personality: music at miles 1, 2, and 3; a cause that resonates (our local library); and a neighborhood that makes a fangirl of us all. If September 19th seems far off (“don’t make me plan that far ahead…”) – it’s not. It’s only 9 weeks. If you were training for a half marathon, 9 weeks wouldn’t be quite enough time.
My Dad
By Ted Williams | | June 19, 2015 Views: My dad always tucks in his shirts. No matter the situation. Before bed, my dad tucks in his t-shirt to his boxer shorts. For about 24 years (ever since I can remember), I’ve been getting made fun of for consistently tucking in my shirt, no matter the situation. Working out at Charlotte Athletic Club? It’s tucked. Casual Mighty Meaty pizza date at Mellow Mushroom? It’s tucked. Barclay Downs neighborhood walk? It’s tucked. I weird people out.
Let’s go shopping…on a budget. Consignment shopping in the Queen City.
By Erin Maddrey | | May 29, 2015 Views: Confession time: I love fashion. To me fashion is more than clothes and accessories…it’s a form of self-expression. Starting at a very young age, my mom instilled in me that fashion is a reflection of mood, of ambition and desires, and of a person’s true self. I consider fashion to be an art form, but like most art, sometimes it’s going to cost you to get quality pieces…unless you know where to go for deals.
The McColl Center for Art + Innovation: Charlotte history, architecture and modern art all in one place. And, it’s free!
By Jonathan Piscitelli | | July 24, 2015 Views: On a cold November night in 1984, the wind whipped against the sturdy stone structure of the abandoned church, as a woman who was homeless crept through the vestibule seeking shelter from the steadily dropping temperatures outside. She built a small fire and added a few chairs to the embers to fight away the chill. Suddenly the flames leapt out of control and within minutes the entire church was ablaze.
How one Charlotte artist managed to quit her job and replace her previous salary with commission revenue
Sydney Durrett loved her full-time job as the design coordinator for custom home builder Corbett Hills Construction. But art had always been her life. For awhile, she tried to do both. “My design job at Corbett Hills Construction was the job I had wanted since college,” said Sydney. ”I told myself I can paint on the side… I can always paint on the side.” And she did keep painting, nearly every day while accepting commissions and selling her work at pop-up shops, until it all just became too much.
Rhino Market opening in Uptown this week. Go inside this cool urban market.
Rhino Market is opening its new Uptown location within a week, according to owner Rob Rondelez. This will be their second market. The original Rhino Market is located in FreeMoreWest. Get ready to crush some Chicken Tortas and sip on one of their 14 draft beers. Easily a top 10 sandwich in Charlotte. via Instagram Rhino Market Uptown will be located across the street from the Mellow Mushroom, near Romare Bearden Park.
Charles Williams' beautiful struggle
By Jonathan Piscitelli | | June 9, 2015 Views: “Be careful Charles. Don’t go jumping waves with your cousins” Charles’ father called from the picnic area. But the boys raced down to the edge of the shore anyway. The sea spray felt cool on their skin as they leapt through the first knee high swells and continued wading into the surf, splashing and laughing in the summer heat. Each successive wave brought with it more laughter as the boys tempted fate and cooled their noon baked skin.
Banana suits to stoplight parties to cuddling: 5 upcoming ridiculous bar crawls you don't want to miss
Because alcohol doesn’t make you laugh hard enough already. Relive your frat party days with the stoplight theme you thought you’d seen the last of your senior year of college. Crawlers will don red, yellow or green outfits depending on their current relationship status (taken, complicated and single, respectively) and hit bars like Fitzgeralds, Tilt on Trade and Whiskey River for drink specials and dancing.
A Charlotte company is reinventing triathlons, but is it enough to bring this sport to the mainstream?
The goal of Major League Triathlon is nothing short of audacious. Daniel and Sarah Cassidy, the husband and wife founders, are setting out to completely reinvent the way triathlons are operated, raced and watched. But the impetus behind this revolution could not be simpler, or more relevant to the future of the sport. The thing about triathlons is that not only are they looooong, but by necessity they are usually held in remote areas, far from urban centers, making them a nightmare for spectators.
So you want to Adopt-A-Stream?
Some of my favorite memories growing up involve my siblings and me “exploring” the creeks near our house. Streams are their own micro-ecosystems, and they have a wonder and mystery incongruous to their proximity to the manmade world. They unassumingly wind their way through the heart of our cities, while supporting an untold collection of natural wonders.
Popular “Moms in Charge” Facebook page shutting down this week - and people are freaking out
The Charlotte Moms in Charge (MICIT) Facebook group became something of a phenomenon in the past year, becoming a go-to source for thousands of women looking to buy and sell used items within a circle of trusted friends. Discussion groups also proliferated on topics including children, travel and home decor.
Get a sneak peek of Gallery Restaurant’s fall menu
Gallery Restaurant, located in the Ballantyne Hotel, is launching a new fall menu October 5. It’s fancy. And fantastic. Restaurant manager Stephen Toth and his extremely knowledgeable and friendly team walked us through an amazing meal including oysters, foie gras, scallops, and a bone-in ribeye bigger than my face. Each dish was presented by the restaurant’s new chef de cuisine Mathew Tilman, who’s only been in the role for two months.
More than words: Charlotte’s arts community responds to the riots
Oftentimes our words fail us. Especially when grappling with sensitive and complex issues, our words can get twisted and misconstrued, our true intentions misunderstood and what started out bad is only made worse. Which is why when the human hurricane of destruction hit Uptown last week and the entire first floor of windows at the Hyatt House were destroyed, manager Matt Allen sent out a call via the Company Store’s Facebook page, asking for help from the Charlotte arts community.
Inside Pineville’s newest thrift concept: Mission Thrift
Mission Thrift, a nonprofit thrift store whose proceeds go toward finding a cure for leprosy, opened late last month in Pineville, bringing a new thrifting concept to the Charlotte area. The store accepts gently used clothes and household items as donations and, similar to other thrift stores, will pick up larger items. Located at 300 S. Polk St., the store is well-styled, including a separate room with children’s toys and a nook to browse books and read.
8 lessons on entrepreneurship from the owners of Charlotte's Cloister Honey
As a writer for Charlotte Agenda, I get to talk to a lot of entrepreneurs. I enjoy the company of driven, focused and passionate people, and I like hearing their stories, it inspires me. The other day I spoke with Joanne de la Rionda and Randall York the owners of Cloister Honey, and although theirs was a story of entrepreneurship, their narrative was tinged with the hard earned realism of two corporate “lifers” who chose to leave their successful careers to pursue the American Dream.
Inside Charlotte's swim team for adults who aren't Olympians
Editor’s note: The author of this article is a coach in the Charlotte Swim Masters program “Nothing fits the body so well as water,” the novelist Don DeLillo said. And there is no exercise like swimming. It engages every muscle group, is an insane cardio workout and because it is low impact, swimming is more than just a sport, it’s a way of life. There’s no reason to stop just because you’re an adult with a job and responsibilities. You were probably on a swim team as a kid.
INSIDER: Here's a sneak peek into the newly renovated Mecklenburg County Aquatic Center
After a year of much-needed renovations, the Mecklenburg County Aquatic Center will be reopening on time and within its $8.6 million budget to host the 2016 Arena Pro Swim Series next week. Its grand re-opening to the public will be June 1. The Aquatic Center first opened in 1991, and at the time was the only 50 meter in-door pool in the area.
How 100 Gardens teaches Charlotte children and feeds the hungry at the same time
A Charlotte nonprofit has figured out a way to educate students using hands-on, real-world applications and to connect young people in Charlotte with the youth of developing countries, all while providing food for the hungry of our community. It might sound like a utopian pipe dream, but it’s real and it’s called 100 Gardens. “100 gardens is a strategy to increase student engagement in schools while addressing health and nutrition,” says co-director Sam Fleming.
Trips for Kids Charlotte teaches kids how to love bikes
There are young people in Charlotte who need our help. Unfortunately, time is that most precious of resources and always in short supply. So it makes sense to give back in a way that you enjoy. If you love mountain biking, being outdoors and having a little exercise thrown into the mix, then Trips for Kids Charlotte is the perfect way to get more involved and have a positive impact on a child’s life.
Top 25 reasons to live in Ballantyne
By Gi Hallmark | | June 26, 2015 Views: It’s come to my attention that there’s a contingent of Charlotteans who think the great suburb of Ballantyne is sub-par. I believe the descriptive phrase “Ballantyne sucks” is used, and 7 times out of 10, Ballantyne is misspelled. While I don’t know the entire basis behind this sentiment, I’d guess that most Ballantyne cynics have never lived in the 28277 and can’t legitimately back up this misanthropic suburbia sentiment.
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