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Results We recruited a real-world cohort of 61 RRMM patients treated with BCMA-directed CAR T cells at our center. Samples of 57 patients were available for single-cell multi-omics profiling: A total of 135 peripheral blood mononuclear cell (PBMC) samples at 3 different time points were collected for single cell RNA, B cell receptor (BCR), TCR and surface protein profiling.
Toward the end of my high school sophomore year, our Spanish teacher organized a trip to see an Andean band perform in Philadelphia. We packed into a van on a Friday evening and headed downtown to a seated auditorium. My 15-year-old classmates and I goaded one another: Who could enjoy the show most ironically? The performers’ clothing seemed odd. The instruments, strange.
Toward the end of my high school sophomore year, our Spanish teacher organized a trip to see an Andean band perform in Philadelphia. We packed into a van on a Friday evening and headed downtown to a seated auditorium. My 15-year-old classmates and I goaded one another: Who could enjoy the show most ironically? The performers’ clothing seemed odd. The instruments, strange.
Zeisel A. M͡oz-Manchado A.B. Codeluppi S. et al. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-Seq. Science. 2015; 347: 1138-1142 Treutlein B. Brownfield D.G. Wu A.R. et al. Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-Seq. Nature. 2014; 509: 371-375 Grün D. Lyubimova A. Kester L. et al. Single-cell messenger RNA sequencing reveals rare intestinal cell types. Nature. 2015; 525: 251-255 Villani A.C. Satija R. Reynolds G. et al.
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