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Keywords TIRF synergy statistical mechanics CoSMoS transcription activation domain intrinsically disordered region Get full text access Log in, subscribe or purchase for full access. References 1. Reményi, A. ∙ Schöler, H.R. ∙ Wilmanns, M. Combinatorial control of gene expression Nat. Struct. Mol. Biol. 2004; 11:812-815 2. Weake, V.M. ∙ Workman, J.L. Inducible gene expression: diverse regulatory mechanisms Nat. Rev. Genet. 2010; 11:426-437 3. Cramer, P.
Abstract Transcription activators are said to stimulate gene expression by ‘recruiting’ coactivators, yet this vague term fits multiple kinetic models. To directly analyze the dynamics of activator–coactivator interactions, single-molecule microscopy was used to image promoter DNA, a transcription activator and the Spt–Ada–Gcn5 acetyltransferase (SAGA) complex within yeast nuclear extract.
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