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JongCheon Na

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Articles

First-in-human and multicenter phase I study of OSCA therapy for knee osteoarthritis

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By Dae Keun Suh, Seunghee Lee, Mijin Kim, Ali Mobasheri, Kyung-Sun Kang, Yohan Bae, Hee-Jin Kang, JongCheon Na, Kyoung Ho Yoon
| Nature Verified
Abstract Knee osteoarthritis is a degenerative joint disease, with no fundamental cure beyond pain relief and anti-inflammation. This phase I, multicenter, open-label, dose-escalation trial evaluated the safety, tolerability, and preliminary efficacy of OSCA, an intra-articular injection co-formulation of osiramestrocel (allogeneic mesenchymal stromal cells) and cartilage acellular matrix, in patients with Kellgren–Lawrence (K&L) grade 2 or 3 knee osteoarthritis.
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