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Jonne M. Draper on Muck Rack

Jonne M. Draper

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Articles

A conserved fertilization complex of Izumo1, Spaca6, and Tmem81 mediates sperm-egg interaction in vertebrates

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By Victoria E. Deneke, Andreas Blaha, Yonggang Lu, Jonne M. Draper
| BioRxiv
New Results doi: https://doi.org/10.1101/2023.07.27.550750 Abstract Fertilization, the fusion of sperm and egg, is essential for sexual reproduction. While several proteins have been demonstrated to be essential for the binding and fusion of gametes in vertebrates, the molecular mechanisms driving this key process are poorly understood. Here, we performed a protein interaction screen using AlphaFold-Multimer to uncover protein-protein interactions in fertilization.
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