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Joomyeong Kim

As seen in: Future Medicine
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Articles

Allele-specific enhancer interaction at the Peg3 imprinted domain

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By Joomyeong Kim, Wesley D. Frey, Kaustubh Sharma, Subash Ghimire
| PLOS
Loading metrics Open Access Peer-reviewed Research Article Joomyeong Kim , Wesley D. Frey, Kaustubh Sharma, Subash Ghimire, Ryoichi Teruyama, Lisa Stubbs Joomyeong Kim, Wesley D.
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Enhancer-driven alternative promoters of imprinted genes

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By Joomyeong Kim, Subash Ghimire
| PLOS
Abstract In the current study, we characterized the expression and histone modification profiles of the alternative promoters found within imprinted Igf2r, Mest, Zac1, Peg3, Snrpn and non-imprinted Myc loci. In terms of expression pattern, the alternative promoters are highly tissue-specific, which is in a stark contrast to the ubiquitous expression of the corresponding main promoters.
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Trans-allelic mutational effects at the Peg3 imprinted locus

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By Corey L Bretz, Joomyeong Kim
| PLOS
How one allele interacts with the other for the function of a gene is not well understood. In this study, we tested potential allelic interaction at the Peg3 imprinted locus with several mutant alleles targeting an Imprinting Control Region, the Peg3-DMR. According to the results, maternal deletion of the Peg3-DMR resulted in 2-fold up-regulation of two paternally expressed genes, Peg3 and Usp29.
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