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Articles by Joon Moon
Single-cell landscape of human adipose tissue reveals THBS1 as a potential driver of fibro-inflammation in metabolic disease
Abstract The cellular complexity of adipose tissue plays a critical role in the pathogenesis of metabolic disease; however, mechanisms underlying adipose dysfunction remain poorly understood. Here, we constructed a single-nucleus and bulk transcriptomic atlas of human visceral adipose tissues from an ethnically homogeneous cohort with defined metabolic states: lean with normal glucose tolerance, obesity, and obesity with type 2 diabetes.
Response kinetics as a dynamic prognostic marker in patients with multiple myeloma
Marker-Free, Automated Eyelid Assessment in Thyroid Eye Disease Using Artificial Intelligence: A Multicenter Validation Study
Keywords Artificial intelligence Deep learning Telemedicine Eyelid retraction Thyroid eye disease Abbreviations and Acronyms AI (artificial intelligence) EMR (electronic medical record) IRB (Institutional Review Board) MAE (mean absolute error) MAPE (mean absolute percentage error) MPLD (mid-pupil to lid distance) MRD1 (margin reflex distance 1) MRD2 (margin reflex distance 2) PCC (Pearson correlation coefficient) SNUBH (Seoul National University Bundang Hospital) ROC (receiver operating...
Longitudinal insights into the natural history of Type 2 diabetes among Koreans: A 20‐year community‐based prospective cohort study
2h-PG 2-h postload glucose ALT alanine aminotransferase ANOVA analysis of variance AST aspartate aminotransferase ATP annual transition probabilities BLSA Baltimore Longitudinal Study of Aging BMI body mass index BP blood pressure BUN blood urea nitrogen CI confidence interval DPP Diabetes Prevention Program FPG fasting plasma glucose GGT gamma-glutamyl transferase HbA1c glycated hemoglobin HDL-C high-density lipoprotein cholesterol HOMA-IR homeostatic model assessment of insulin resistance...
Pancreatic beta‐cell mass and function and therapeutic implications of using antidiabetic medications in type 2 diabetes
INTRODUCTION Type 2 diabetes mellitus is a multifaceted metabolic disorder principally characterized by insulin resistance and a progressive impairment in insulin secretion1. At the core of type 2 diabetes mellitus pathogenesis lies a dynamic interplay between insulin resistance and pancreatic β-cell dysfunction1. In the early stages of type 2 diabetes mellitus, pancreatic β-cells undergo compensatory hyperplasia and enhanced insulin secretion to offset rising metabolic demands2.
Multiparity increases the risk of diabetes by impairing the proliferative capacity of pancreatic β cells
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Progressive reduction in basal ganglia explains and predicts cerebral structural alteration in type 2 diabetes
Introduction Type 2 diabetes is a common disease that impacts more than 360 million people worldwide.1 Patients with type 2 diabetes show cognitive and mood impairment, indicating a potential for brain injury in regions that control these functions.
Real-world data of long-term survival in patients with T-cell lymphoma who underwent stem cell transplantation - Blood Cancer Journal
Abstract This study aimed to identify the benefits of autologous-stem cell transplantation (auto-SCT) and allogeneic-SCT (allo-SCT) in patients with aggressive T-cell lymphomas to aid in the selection of transplantation type in clinical practice. This study retrospectively analyzed data from 598 patients who underwent transplantation for T-cell lymphomas from 2010 to 2020. In total, 317 patients underwent up-front SCT as consolidation therapy.
Light and shade of ruxolitinib: positive role of early treatment with ruxolitinib and ruxolitinib withdrawal syndrome in patients with myelofibrosis
Declaration of Interest The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Keeping a balance in chronic lymphocytic leukemia (CLL) patients taking ibrutinib: ibrutinib-associated adverse events and their management based on drug interactions: Expert Review of Hematology: Vol 14, No 9
Hee Jeong ChoDepartment of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South KoreaView further author information Dong Won BaekDepartment of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South KoreaView further author information Juhyung KimDepartment of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook...
Therapeutic strategies, including allogeneic stem cell transplantation, to overcome relapsed/refractory adult T-cell acute lymphoblastic leukemia
Dong Won BaekDepartment of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South KoreaView further author information Jung Min LeeDepartment of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South KoreaView further author information Juhyung KimDepartment of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook...
SGLT2 inhibition reduces cellular senescence in the diabetic kidney by promoting ketone body‐induced NRF2 activation
ORIGINAL ARTICLE Mi Na Kim, Department of Translational Medicine, Seoul National University College of Medicine, Seoul, South Korea Contributed equally to this work Search for more papers by this author Joon Ho Moon, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea Contributed equally to this work Search for more papers by this author Young Min Cho, Corresponding Author ymchomd@snu.ac.kr orcid.org/0000-0002-2331-6126 Department of Translational Medicine,...
References: Hypomethylating agent-based post-transplant strategies to maximize the outcome of high-risk acute myeloid leukemia after allogeneic stem cell transplantation
One plus one does not always equal two, especially with regard to hypomethylating agents: the question of synergy of azacitidine and lenalidomide for treatment of relapsed acute myeloid leukemia and myelodysplastic syndromes post allogeneic hematopoietic stem cell transplant
Hypomethylating agent-based post-transplant strategies to maximize the outcome of high-risk acute myeloid leukemia after allogeneic stem cell transplantation: Expert Review of Hematology: Vol 13, No 9
ABSTRACT Introduction Clinical outcomes of patients diagnosed with high-risk acute myeloid leukemia (AML) are poor, and relapse or refractoriness is main cause of treatment failure, even in those who underwent standard allogeneic stem cell transplantation (allo-SCT). Therefore, innovative or additional approaches are necessary to overcome refractoriness to the graft-versus-leukemia (GVL) effect immediately after allo-SCT.
Lactation improves pancreatic β cell mass and function through serotonin production
Research ArticleMetabolism Joon Ho Moon1,2,*, Hyeongseok Kim1,3,*, Hyunki Kim1, Jungsun Park1, Wonsuk Choi1, Wongun Choi1, Hyun Jung Hong4, Hyun-Joo Ro5,6, Sangmi Jun5,6, Sung Hee Choi2, Ronadip R. Banerjee7, Minho Shong4, Nam Han Cho8, Seung K. Kim9, Michael S. German10,†, Hak Chul Jang2,† and Hail Kim1,† 1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Serotonergic regulation of energy metabolism in peripheral tissues
Introduction Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine that mediates a range of central and peripheral functions. It is synthesized from the essential amino acid tryptophan by the sequential actions of the rate-limiting enzyme tryptophan hydroxylase (TPH) and aromatic acid decarboxylase (AADC). Most 5-HT is degraded by monoamine oxidase (MAO) to 5-hydroxyindole aldehyde, which is subsequently metabolized to 5-hydroxyindoleacetic acid (5-HIAA) by aldehyde dehydrogenase (Keszthelyi et al.
Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation
Islet Studies Abstract A sufficient β-cell mass is crucial for preventing diabetes, and perinatal β-cell proliferation is important in determining the adult β-cell mass. However, it is not yet known how perinatal β-cell proliferation is regulated. Here, we report that serotonin regulates β-cell proliferation through serotonin receptor 2B (HTR2B) in an autocrine/paracrine manner during the perinatal period.
Carbonization/Oxidation-Mediated Synthesis of MOF-Derived Hollow Nanocages of ZnO/N-doped Carbon Interwoven by Carbon Nanotubes for Lithium-Ion Battery Anodes
Carbonization/Oxidation-Mediated Synthesis of MOF-Derived Hollow Nanocages of ZnO/N-doped Carbon Interwoven by Carbon Nanotubes for Lithium-Ion Battery Anodes Transition metal oxide (TMO)-based anode materials for Li-ion batteries (LIBs) have generally suffered from limitations of intrinsically severe pulverization upon lithiation and reduced electrical conductivity.
Joon Moon, finding a vintage soul in rock
Joon Moon performing at Mercury Lounge. — AFP picNEW YORK, Oct 13 — Composing songs initially just for voice and piano, the veteran musicians behind Joon Moon quickly knew they could create a richer sound — something more vintage from the earlier days of rock and soul. The French-American trio, whose members hail from different musical backgrounds, has pulled together their influences in an album that is at once open in approach, tight in production and smoky in texture.
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