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Na Keum Lee on Muck Rack

Na Keum Lee

As seen in: Nature
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Articles

Single-cell landscape of human adipose tissue reveals THBS1 as a potential driver of fibro-inflammation in metabolic disease

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By Jisu Jung, Eun Seo Park, Jung-jae Lee, Hyung Joon Kim, Jae Myoung Suh, Jae Bum Kim, Joon Moon, Jong Kyoung Kim, Sung Hee Choi, Na Keum Lee, Uijin Juang, Qingzhi Huang, Jung-Kwon Kim
| Nature Verified
Abstract The cellular complexity of adipose tissue plays a critical role in the pathogenesis of metabolic disease; however, mechanisms underlying adipose dysfunction remain poorly understood. Here, we constructed a single-nucleus and bulk transcriptomic atlas of human visceral adipose tissues from an ethnically homogeneous cohort with defined metabolic states: lean with normal glucose tolerance, obesity, and obesity with type 2 diabetes.
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