Jordan C. Barone
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Peripheral cyclical expression of GABA-A receptor subunit genes and menstrual cycle affective change: a dimensional, transdiagnostic study - Translational Psychiatry
Abstract Menstrual cycle affective change (MCAC), including conditions like Premenstrual Dysphoric Disorder (PMDD), is triggered by ovarian hormone fluctuations, but its neurobiological mechanisms remain poorly understood. A leading hypothesis implicates abnormal GABA-A receptor (GABAAR) subunit regulation in altering sensitivity to neuroactive steroids, a theory difficult to test in humans.
Biomarker development for menstrual cycle affective change: the need for greater temporal, mechanistic, and phenotypic specificity - Neuropsychopharmacology
Approximately 6% of ovulating individuals experience the debilitating affective symptoms of Premenstrual Dysphoric Disorder (PMDD), which arise premenstrually and remit post-menses [1]. Meanwhile, nearly 60% of female patients with depression experience cyclical worsening similar to PMDD but without full post-menstrual remission, termed Perimenstrual Exacerbation (PME) [2].
GnRH Analogs in Premenstrual Dysphoric Disorder: Review and Practical Guideline
ABSTRACT Objective: Despite the documented success of gonadotropin-releasing hormone analogs (GnRHa) for the treatment of treatment-resistant premenstrual dysphoric disorder (PMDD), many patients struggle to find providers who have sufficient knowledge of PMDD and its evidence-based treatments and/or who are comfortable treating PMDD after first-line treatment options have failed.
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