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Jordy H. Lam

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Structure-guided design of partial agonists at an opioid receptor - Nature Communications

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By Sarah M. Bernhard, Jordy H. Lam, Jhoan S. Aguilar, Kevin Appourchaux, Elyssa B. Margolis, Jonathan Fay, Amynah Pradhan, Vsevolod Katritch, Jay McLaughlin, Susruta Majumdar
| Nature Verified
Abstract Chronic pain and opioid overdose deaths highlight the need for non-addictive analgesics with novel mechanisms. The δ opioid receptor (δOR) is a promising target, as it lacks the respiratory depression associated with µ opioid receptor (µOR) agonists. However, early δOR full agonists caused seizures, limiting their clinical use.
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