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Jorgaq Pata

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Articles

Cryo-EM of ATP-driven dynamics and itraconazole binding of the fungal drug efflux ABC pump Candida glabrata Cdr1

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By Benjamin Wiseman, Eleftherios Zarkadas, Jorgaq Pata
| BioRxiv
Abstract Azole resistance in Candida species is often caused by the overexpression of Cdr1. Despite its clinical relevance, the structural basis for its ATP-driven efflux pump function remains elusive. We present four high-resolution cryo-EM structures for Candida glabrata Cdr1 under active turnover conditions in the absence and presence of ATP-Mg, itraconazole, and vanadate.
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