Jose M Abril on Muck Rack

Jose M Abril

Spain
As seen in: eLife
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Articles

Competition for the conserved branch point sequence influences physiological outcomes in pre-mRNA splicing

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By Jose M Abril, Kuo-Chieh Liao, Haiping Hao
| eLife
eLife Assessment This important manuscript provides insights into the competition between Splicing Factor 1 (SF1) and Quaking (QKI) for binding at the ACUAA branch point sequence in a model intron, regulating exon inclusion. The study employs convincing, rigorous transcriptomic, proteomic, and reporter assays, with both mammalian cell culture and yeast models.
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